Mohamed Hamdy began his career in the youth ranks of Al Ahly before eventually settling with Pyramids FC in 2018 after impressing greatly with Al Masry Club.Hamdy spent six months on loan with Arab Contractors Club, joining their ranks on January 26, 2016. On June 30, 2016, Al Masry Club successfully signed him on a free transfer for a duration of three seasons. He was among the players officially released by Al Ahly during that season.Hamdy has had a balanced international career, becoming a key pillar for the national team in the left-back position in recent years. He has earned the trust of all his coaches.